Plasticity in cortical networks & epilepsy


Selected publications


GABAA receptor dependent synaptic inhibition tunes KCC2 activity via the Cl-sensitive WNK1 kinase.

Heubl M, Zhang J, Pressey JC, Al Aabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugene E, Russeau M, Kahle K, Poncer JC, Lévi S

Nat. Comm. 2017 8:1776

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA

Nat. Comm. 2017 8:15592


Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.

Fernandez, SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P

Brain Struct Funct 2016 22: 4007-4025


KCC2 gates activity-driven AMPA receptor traffic through cofilin phosphorylation.

Chevy Q, Heubl M, Goutierre M, Backer S, Moutkine I, Eugène E, Bloch-Gallego E, Lévi S, Poncer JC.

J Neurosci. 2015 35: 15772-15786


Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses.

Lévi S, Le Roux N, Eugene E, Poncer JC.

Neuropharmacology 2015 88: 199-208


An organotypic brain slice preparation from adult patients with temporal lobe epilepsy.

Eugene E, Cluzeaud F, Cifuentes-Diaz C, Fricker D, Le Duigou C, Clemenceau S, Baulac M, Poncer JC, Miles R

J Neurosci. Meth. 2014 235: 234-44


Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering and function in hippocampal neurons.

Chamma I, Heubl M, Chevy Q, Renner M, Eugene E, Moutkine I, Poncer JC, Lévi S.

J Neurosci. 2013 33:15488-15503


Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus

Cabezas C, Irinopoulou T, Cauli B, Poncer JC.

Front Neural Circuits 2013 7:60


Input specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons.

Le Roux N, Cabezas C, Böhm UL, Poncer JC.

J Physiol. 2013 591:1809-22


Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses.

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC.

J Neurosci. 2012 32:11835-40


Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.

Chamma I, Chevy Q, Poncer JC¤, Lévi S¤.

Frontiers Cell Neurosci. 2012 6:5


A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors.

Bouthour W*, Leroy F*, Emmanuelli C, Le Roux N, Carnaud M, Poncer JC, Lévi S.

Cereb Cortex 2012 22:1542-53


The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines.

Gauvain G, Chamma I*, Chevy Q*, Cabezas C, Irinopoulou T, Bodrug N, Carnaud M, Lévi S¤, Poncer JC¤.

Proc Natl Acad Sci U S A 2011 108:15474-9


Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy.

Saint-Martin C*, Gauvain G*, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, Maljevic S, Ernst JP, Garcia-Olivares J, Fahlke C, Nabbout R, LeGuern E, Lerche H, Poncer JC¤, Depienne C¤.

Hum Mutat. 2009 30:397-405


GABA(A) receptor gamma 2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition.

Eugène E, Depienne C, Baulac S, Baulac M, Fritschy JM, Le Guern E, Miles R, Poncer JC.

J Neurosci. 2007 27:14108-16


Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses.

Scheuber A*, Rudge R*, Danglot L*, Raposo G, Binz T, Poncer JC, Galli T.

Proc Natl Acad Sci U S A. 2006 103:16562-7


Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.

Scheuber A, Miles R, Poncer JC.

J Neurosci. 2004 24:10402-9


Hippocampal long term potentiation: silent synapses and beyond.

Poncer JC.

J Physiol Paris 2003 97:415-22


Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II.

Poncer JC, Esteban JA, Malinow R.

J Neurosci. 2002 22:4406-11


Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics.

Poncer JC, Malinow R.

Nat Neurosci. 2001 4:989-96


Differential control of GABA release at synapses from distinct interneurons in rat hippocampus.

Poncer JC, McKinney RA, Gahwiler BH, Thompson SM.

J Physiol. 2000 528:123-30


Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R.

Science 2000 287:2262-7


Either N- or P-type calcium channels mediate GABA release at distinct hippocampal inhibitory synapses.

Poncer JC, McKinney RA, Gähwiler BH, Thompson SM.

Neuron 1997 18:463-72


Paired recordings from neurones.

Miles R, Poncer JC.

Curr Opin Neurobiol. 1996 6:387-94


Modulation of synaptic GABAA receptor function by benzodiazepines in area CA3 of rat hippocampal slice cultures.

Poncer JC, Dürr R, Gähwiler BH, Thompson SM.

Neuropharmacology 1996 35:1169-79


Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus.

Poncer JC, Shinozaki H, Miles R.

J Physiol. 1995 485:121-34


Metabotropic glutamate receptors mediate a post-tetanic excitation of guinea-pig hippocampal inhibitory neurones.

Miles R, Poncer JC.

J Physiol. 1993 463:461-73