Plasticity in cortical networks & epilepsy


Selected publications

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy.

Ribierre T, Bacq A, Donneger F, Doladilhe M, Maletic M, Roussel D, Le Roux I, Chassoux F, Devaux B, Adle-Biassette H, Ferrand-Sorbets S, Dorfmüller G, Chipaux M, Baldassari S, Poncer JC, Baulac S. Nature Neuroscience 2024

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy.

Donneger F, Zanin A, Besson J, Kadiri Y, Pagan C, David N, Russeau M, Bielle F, Devaux B, Mathon B, Navarro V, Chassoux F, Poncer JC.

bioRxiv 2023

Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory.

Simonnet C, Sinha M, Goutierre M, Moutkine I, Daumas S, Poncer JC.

Neuropsychopharmacology 2023 48:1067-1077

Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons

Al Awabdh S, Donneger F, Goutierre M, Séveno M, Vigy O, Weinzettl P, Russeau M, Moutkine I, Lévi S, Marin P, Poncer JC.

J Neurosci. 2022 42:166-182

The Multifaceted Roles of KCC2 in Cortical Development.

Virtanen MA, Uvarov P, Mavrovic M, Poncer JC, Kaila K.

Trends Neurosci. 2021 44: 378-392

Convergence of adenosine and GABA signaling for synapse stabilization during development.

Gomez-Castro F, Zappettini S, Pressey JC, Silva CG, Russeau M, Gervasi N, Figueiredo M, Montmasson C, Renner M, Canas PM, Gonçalves FQ, Alçada-Morais S, Szabó E, Rodrigues RJ, Agostinho P, Tomé AR, Caillol G, Thoumine O, Nicol X, Leterrier C, Lujan R, Tyagarajan SK, Cunha RA, Esclapez M, Bernard C, Lévi S.

Science 2021 374:eabk2055

Molecular Crowding and Diffusion-Capture in Synapses.

Kokolaki ML, Fauquier A, Renner M.

iScience. 2020 23: 101382

Cation-chloride cotransporters and the polarity of GABA signaling in mouse hippocampal parvalbumin interneurons.

Otsu Y, Donneger F, Schwartz EJ, Poncer JC.

J Physiol (London). 2020 598: 1865-1880

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.

Goutierre M, Al Awabdh S, Donneger F, François E, Gomez-Dominguez D, Irinopoulou T, Menendez de la Prida L, Poncer JC.

Cell Reports. 2019 28:91-103

KCC2 membrane diffusion tunes neuronal chloride homeostasis.

Côme E, Marques X, Poncer JC, Lévi S.

Neuropharmacology. 2019 3908: 30091-30097

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity.

Côme E, Heubl M, Schwartz EJ, Poncer JC, Lévi S.

Front Cell Neurosci. 2019 13:48

Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAA Receptor Diffusion.

Battaglia S, Renner M, Russeau M, Côme E, Tyagarajan SK, Lévi S.

eNeuro 2018 5(1)

GABAA receptor dependent synaptic inhibition tunes KCC2 activity via the Cl-sensitive WNK1 kinase.

Heubl M, Zhang J, Pressey JC, Al Aabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugene E, Russeau M, Kahle K, Poncer JC, Lévi S

Nat. Comm. 2017 8:1776

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA

Nat. Comm. 2017 8:15592


Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.

Fernandez, SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P

Brain Struct Funct 2016 22: 4007-4025


KCC2 gates activity-driven AMPA receptor traffic through cofilin phosphorylation.

Chevy Q, Heubl M, Goutierre M, Backer S, Moutkine I, Eugène E, Bloch-Gallego E, Lévi S, Poncer JC.

J Neurosci. 2015 35: 15772-15786


Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses.

Lévi S, Le Roux N, Eugene E, Poncer JC.

Neuropharmacology 2015 88: 199-208


An organotypic brain slice preparation from adult patients with temporal lobe epilepsy.

Eugene E, Cluzeaud F, Cifuentes-Diaz C, Fricker D, Le Duigou C, Clemenceau S, Baulac M, Poncer JC, Miles R

J Neurosci. Meth. 2014 235: 234-44


Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering and function in hippocampal neurons.

Chamma I, Heubl M, Chevy Q, Renner M, Eugene E, Moutkine I, Poncer JC, Lévi S.

J Neurosci. 2013 33:15488-15503


Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus

Cabezas C, Irinopoulou T, Cauli B, Poncer JC.

Front Neural Circuits 2013 7:60


Input specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons.

Le Roux N, Cabezas C, Böhm UL, Poncer JC.

J Physiol (London). 2013 591:1809-22


Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses.

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC.

J Neurosci. 2012 32:11835-40


Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.

Chamma I, Chevy Q, Poncer JC¤, Lévi S¤.

Frontiers Cell Neurosci. 2012 6:5


A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors.

Bouthour W*, Leroy F*, Emmanuelli C, Le Roux N, Carnaud M, Poncer JC, Lévi S.

Cereb Cortex 2012 22:1542-53


The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines.

Gauvain G, Chamma I*, Chevy Q*, Cabezas C, Irinopoulou T, Bodrug N, Carnaud M, Lévi S¤, Poncer JC¤.

Proc Natl Acad Sci U S A 2011 108:15474-9


Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy.

Saint-Martin C*, Gauvain G*, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, Maljevic S, Ernst JP, Garcia-Olivares J, Fahlke C, Nabbout R, LeGuern E, Lerche H, Poncer JC¤, Depienne C¤.

Hum Mutat. 2009 30:397-405


GABA(A) receptor gamma 2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition.

Eugène E, Depienne C, Baulac S, Baulac M, Fritschy JM, Le Guern E, Miles R, Poncer JC.

J Neurosci. 2007 27:14108-16


Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses.

Scheuber A*, Rudge R*, Danglot L*, Raposo G, Binz T, Poncer JC, Galli T.

Proc Natl Acad Sci U S A. 2006 103:16562-7


Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.

Scheuber A, Miles R, Poncer JC.

J Neurosci. 2004 24:10402-9


Hippocampal long term potentiation: silent synapses and beyond.

Poncer JC.

J Physiol Paris 2003 97:415-22


Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II.

Poncer JC, Esteban JA, Malinow R.

J Neurosci. 2002 22:4406-11


Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics.

Poncer JC, Malinow R.

Nat Neurosci. 2001 4:989-96


Differential control of GABA release at synapses from distinct interneurons in rat hippocampus.

Poncer JC, McKinney RA, Gahwiler BH, Thompson SM.

J Physiol. 2000 528:123-30


Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R.

Science 2000 287:2262-7


Either N- or P-type calcium channels mediate GABA release at distinct hippocampal inhibitory synapses.

Poncer JC, McKinney RA, Gähwiler BH, Thompson SM.

Neuron 1997 18:463-72


Paired recordings from neurones.

Miles R, Poncer JC.

Curr Opin Neurobiol. 1996 6:387-94


Modulation of synaptic GABAA receptor function by benzodiazepines in area CA3 of rat hippocampal slice cultures.

Poncer JC, Dürr R, Gähwiler BH, Thompson SM.

Neuropharmacology 1996 35:1169-79


Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus.

Poncer JC, Shinozaki H, Miles R.

J Physiol. 1995 485:121-34


Metabotropic glutamate receptors mediate a post-tetanic excitation of guinea-pig hippocampal inhibitory neurones.

Miles R, Poncer JC.

J Physiol. 1993 463:461-73